What Is NAD+?
Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme found in every living cell. It is essential for converting food into cellular energy (ATP), repairing damaged DNA, activating sirtuins (longevity proteins), and maintaining healthy mitochondrial function.
NAD+ levels decline naturally with age — by age 50, most adults have approximately 50% less NAD+ than they did at age 20. This decline is associated with fatigue, cognitive fog, slower metabolism, reduced recovery capacity, and accelerated aging.
Supplemental NAD+ therapy aims to restore youthful cellular energy levels, supporting everything from brain function and metabolic rate to immune resilience and physical recovery.
How NAD+ Therapy Works
- Mitochondrial Energy Production: NAD+ is a critical substrate in the electron transport chain — the process by which your mitochondria produce ATP (cellular fuel). More NAD+ = more efficient energy production at the cellular level.
- Sirtuin Activation: NAD+ activates sirtuins (SIRT1–SIRT7), a family of proteins involved in DNA repair, inflammation regulation, stress resistance, and metabolic homeostasis. Sirtuins are often called "longevity genes."
- DNA Repair: The enzyme PARP1, which repairs damaged DNA, requires NAD+ as fuel. As NAD+ declines, DNA damage accumulates — a hallmark of aging.
- Circadian Rhythm Support: NAD+ levels fluctuate with your circadian clock. Restoring optimal levels can improve sleep quality and metabolic timing.
- Neuroprotection: Emerging research suggests NAD+ supplementation may support neuronal health, cognitive function, and resistance to neurodegenerative processes.
Restore Your Cellular Energy
Clinician-prescribed NAD+ therapy from $199/mo. Licensed US pharmacies. 2-day UPS shipping.
Start Your AssessmentWho Benefits from NAD+ Therapy?
- Adults over 35 experiencing age-related fatigue and cognitive decline
- Athletes and active individuals seeking faster recovery and sustained energy
- Professionals needing enhanced focus, mental clarity, and cognitive performance
- Anyone pursuing proactive longevity and anti-aging strategies
- Individuals with metabolic slowdown or stubborn weight plateau
NAD+ vs. NMN vs. NR: What's the Difference?
| Factor | NAD+ (Direct) | NMN | NR (Niagen) |
|---|---|---|---|
| Delivery | Injection/IV (direct) | Oral supplement | Oral supplement |
| Bioavailability | Highest (bypasses gut) | Moderate | Moderate |
| Speed of Effect | Immediate cellular access | Requires conversion to NAD+ | Requires conversion to NAD+ |
| Clinical Oversight | Clinician-prescribed | OTC supplement | OTC supplement |
| Best For | Serious optimization | General maintenance | General maintenance |
The Telehealth FX NAD+ Protocol
Health Assessment
Complete an online questionnaire covering your energy levels, cognitive function, sleep quality, and health goals.
Clinician Review
A licensed provider reviews your profile and determines the optimal NAD+ protocol and dosing for your needs.
Pharmacy Compounding
Your NAD+ is compounded by a licensed US pharmacy and shipped via 2-day UPS directly to your door.
Ongoing Optimization
Regular check-ins with your care team to track progress, adjust dosing, and optimize your longevity protocol.
Start Your NAD+ Protocol
From $199/mo. Clinician-prescribed cellular energy therapy. Licensed US pharmacies. 2-day shipping.
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